The allele-frequency spectrum in a decoupled Moran model with mutation, drift, and directional selection, assuming small mutation rates
نویسندگان
چکیده
منابع مشابه
Purifying selection, drift, and reversible mutation with arbitrarily high mutation rates.
Some species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the resulting high diversity levels within a population (hyperdiversity) mean that standard population genetics methods are not trustworthy. We analyze a population ...
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The evolution of the allelic proportion x of a biallelic locus subject to the forces of mutation and drift is investigated in a diffusion model, assuming small scaled mutation rates. The overall scaled mutation rate is parametrized with θ = (μ1+μ0)N and the ratio of mutation rates with α = μ1/(μ1+μ0) = 1−β. The equilibrium density of this process is beta with parameters αθ and βθ. Away from equ...
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The growing probabilities of additional offspring with the beneficial reversal allele for various population sizes, N , sequence lengths, L, selective advantages, s, fitness parameters, k, and measuring parameters, C, were calculated in an asymmetric sharply-peaked landscape using the decoupled continuous-time mutation-selection model. The growing probability in the stochastic region was invers...
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In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore the power of the likelihood ratio tests (LRT) of neutrality for varying levels of mutation and sel...
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ژورنال
عنوان ژورنال: Theoretical Population Biology
سال: 2012
ISSN: 0040-5809
DOI: 10.1016/j.tpb.2012.01.001